| Cat. No. |
Product Name |
Information |
| PC-27851 |
S-023-0996
EZH2/EGFR inhibitor
|
S-023-0996 is a potent, tumor cell selective, dual inhibitor of EZH2 and EGFR with IC50 of 2.41 nM and 42.18 nM respectively, inhibits tumor cell proliferation, migration and invasion in vitro with superior efficacy and safety than individual drug combinations. |
| PC-27770 |
FCD-11
SET1A/COMPASS inhibitor
|
FCD-11 is a first-in-class, selective small molecule inhibitor of histone methyltransferases COMPASS (Complex of proteins associated with Set1), specifically inhibits the H3K4me3 activity of SET1A/COMPASS and MLL1/COMPASS with IC50 of 1.32 uM and 3.26 uM. |
| PC-27763 |
METTL21A-IN-1
METTL21A inhibitor
|
METTL21A-IN-1 (Compound 6d) is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A, highly selective against a panel of 44 human MTases. |
| PC-27762 |
HK262
METTL21A inhibitor
|
HK262 is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A with IC50 of 1.1 uM. |
| PC-27104 |
MS3-123
PRMT1 inhibitor
|
MS3-123 is a highly potent, selective and covalent inhibitor of PRMT1 with IC50 of 11.4 nM, targeting the unique Cys119 within the SAM-binding pocket of PRMT1. |
| PC-26787 |
TNG456
PRMT5 inhibitor
|
TNG456 is a potent, highly selective, brain-penetrant MTA-cooperative PRMT5 inhibitor with Ki,app of <2 pM, exhibits viability growth inhibition with GI50 of 20 nM for HAP1 MTAP-null cells, 50-fold selective over HAP1 MTAP WT cells. |
| PC-26591 |
NSUN2 inhibitor AK
NSUN2 inhibitor
|
NSUN2 inhibitor AK (AK-968/36977265) is a small molecule inhibitor of RNA methyltransferase NSUN2, decreases m5C occupancy and GATM mRNA levels, shows anti-fibrotic efficacy. |
| PC-26384 |
METTL9i
METTL9 inhibitor
|
METTL9i is a first-in-class, highly potent, selective and cell-active methyltransferase METTL9 inhibitor with IC50 of 67 nM. |
| PC-26021 |
YL-5092
YTHDC1 inhibitor
|
YL-5092 is a highly potent and selective, first-in-class inhibitor of RNA m6A reader YTHDC1 with IC50 of 7.4 nM and SPR Kd of 29.6 nM. |
| PC-25924 |
DC2-C1
YTHDC2 inhibitor
|
DC2-C1 is a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2 with IC50 of 168 nM in FP assays, high selectivity over other YTH-domain proteins. |
| PC-25914 |
FLAV-27
G9a inhibitor
|
FLAV-27 is a potent, selective, SAM-competitive, brain-penetrant inhibitor of histone methyltransferase G9a with IC50 of 0.6 nM, with excellent selectivity over GLP (3.2% inhibition at 1 uM). |
| PC-25825 |
I3IN-002
IGF2BP3 inhibitor
|
I3IN-002 is a small molecule inhibitor of RNA-binding protein IGF2BP3, inhibits IGF2BP3-RNA interactions and shows leukemic cell growth-inhibitory activity with IC50 of ~2 µM in wild-type SEM-cells. |
