| Cat. No. |
Product Name |
Information |
| PC-28740 |
CBX2-IN-1
CBX2 inhibitor
|
CBX2-IN-1 (Compound 37) is a non-peptidic small molecule CBX2 inhibitor with IC50 of 9.6 uM, interacts with H3K27me3 peptide binding channel of CBX2. |
| PC-28674 |
STM9005
METTL1 inhibitor
|
STM9005 is a potent, highly specific inhibitor of m7G methyltransferase METTL1, inhibits recombinant METTL1 enzyme activity with an IC50 < 13 nM and SPR Kd of 2 nM, affects METTL1-mediated m7G modification in cancer cells. |
| PC-28659 |
DCLX069
PRMT1 inhibitor
|
DCLX069 (DCLX-069) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 17.9 uM, is less active against PRMT4 and PRMT6. |
| PC-28639 |
XSY12
NSD3 degrader
|
XSY12 is a hydrophobic-tag degrader of the NSD3 PWWP domain that enables cellular NSD3 depletion (DC50=2.21 μM, Dmax=80.2%), promotes proteasome-dependent NSD3 depletion, reduces H3K36 methylation, and induces apoptosis and G2/M arrest in NSD3-dependent models. |
| PC-28197 |
METTL1 inhibitor B22
METTL1 inhibitor
|
METTL1 inhibitor B22 is a specific small molecule inhibitor of RNA methyltransferase METTL1 with IC50 of 1 uM, selective against a panel of 7 HMTases and the RNA-methyltransferase METTL3/METTL14. |
| PC-28196 |
EZM8266
G9a inhibitor
|
EZM8266 is a potent, selective and orally active G9a (histone lysine methyltransferase 2, EHMT2) inhibitor with IC50 of 1 pM for human EHMT2, effectively reduces H3K9me2 levels. |
| PC-28173 |
TRDMT1i
TRDMT1 inhibitor
|
TRDMT1i (YW1842, YW-1842) is a potent small molecule inhibitor of RNA methyltransferase TRDMT1, blocks TRDMT1-mediated m5C formation in DNA-RNA hybrids in vitro and reduces the viability of cancer cell lines. |
| PC-28117 |
TR-07 hydrochloride
PRMT1 activator
|
PRMT1 activator TR-07 hydrochloride is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro. |
| PC-28112 |
PRMT1 activator TR-07
PRMT1 activator
|
PRMT1 activator TR-07 is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro. |
| PC-28089 |
LEM-06
NSD2 inhibitor
|
LEM-06 is a small molecule inhibitor of histone methyltransferase NSD2 with IC50 of 0.8 mM against H3K36 methylation in vitro. |
| PC-28088 |
NSD2 inhibitor PTD2
NSD2 inhibitor
|
NSD2 inhibitor PTD2 is a peptide derived from histone H4 sequence and inhibitor for the histone methyltransferase WHSC1 (Nuclear receptor-binding SET domain protein 2, NSD2, MMSET) with SPR KD of 3.0 uM, IC50 of 22 uM and 3.2 uM for NSD2 and NSD3 respectively. |
| PC-28070 |
AZD3632
Menin inhibitor
|
AZD3632 (AZD-3632) is a potent, selective and orally active second-generation menin inhibitor, disrupts the Menin-KMT2A complex, suppresses leukemogenic transcription and promotes malignant cell differentiation. |
