| Cat. No. |
Product Name |
Information |
| PC-72046 |
MI-3454
menin-MLL1 inhibitor
|
MI-3454 (MI 3454) is a highly potent, orally bioavailable inhibitor of the menin-MLL1 interaction with IC50 of 0.51 nM, 60-fold improvement over MI-503. |
| PC-72045 |
F5446
SUV39H1 inhibitor
|
F5446 (F 5446) is a specific small molecule inhibitor of H3K9me3-specific histone methyltransferase SUV39H1 with EC50 of 0.496 uM in an in vitro enzymatic activity assay. |
| PC-72008 |
TC-5115
MLL1 SET domain
|
TC-5115 (TC5115 ) is a potent, selective inhibitor of MLL1 SET domain with IC50 of 15 nM, 48 times more potent than the pan-methyltransferase inhibitor SAH. |
| PC-38300 |
MS1943
EZH2 degrader
|
MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM. |
| PC-38218 |
BAY-155
menin-MLL inhibitor
|
BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503. |
| PC-38209 |
DC541
NTMT1 inhibitor
|
DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM. |
| PC-38151 |
SHIN1
SHMT1/2 inhibitor
|
SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM. |
| PC-38150 |
SHIN2
SHMT1/2 inhibitor
|
SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1. |
| PC-38010 |
MU1656
DOT1L inhibitor
|
MU1656 (MU 1656 ) is a potent, highly selective inhibitor of histone methyltransferase DOT1L with IC50 of 2 nM. |
| PC-36120 |
WDR5 WIN site inhibitor C3
WDR5 inhibitor
|
WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM. |
| PC-36119 |
WDR5 WIN site inhibitor C6
WDR5 inhibitor
|
WDR5 inhibitor C6 (WDR5-IN-4) is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM. |
| PC-36041 |
NPD13668
EZH2 inhibitor
|
NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels. |
