EML425 | CBP/p300 inhibitor | Probechem Biochemicals

Chemical Structure : EML425

CAS No.: 1675821-32-5

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EML425 (EML-425)

货号: PC-22924Not For Human Use, Lab Use Only.

EML425 is a potent, selective, cell-permeable and reversible inhibitor of KAT3 histone acetyltransferases (CBP and p300) with IC50 of 1.1 and 2.9 uM respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

EML425 is a potent, selective, cell-permeable and reversible inhibitor of KAT3 histone acetyltransferases (CBP and p300) with IC50 of 1.1 and 2.9 uM respectively.
EML425 is inactive against the enzymes GCN5 and PCAF.
EML425 (50-100 uM) induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9 in human leukemia U937 cells, a marked arrest in the G0/G1 phase.
EML425 is more potent and selective than curcumin and anacardic acid, with a potency comparable to that of C646.
EML425 is an invaluable chemical probe not only for mechanistic studies of p300-mediated lysine acetylation but also to further investigate the biological role of KAT3 enzymes.

物理化学性质&存储条件

分子量	440.50
分子式	C27H24N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione

参考文献

1. Milite C, et al. J Med Chem. 2015 Mar 26;58(6):2779-98.

EML425 (EML-425)

生物&药学活性

物理化学性质&存储条件

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EML425 (EML-425)

生物&药学活性

物理化学性质&存储条件

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