| Cat. No. |
Product Name |
Information |
| PC-49718 |
TCPOBOP
CAR agonist
|
TCPOBOP is a phenobarbital-like class of CYP-inducing agent and agonist ligand for constitutive androstane receptor (CAR) with EC50 of 20 nM. |
| PC-49717 |
S07662
CAR inhibitor
|
S07662 is a human constitutive androstane receptor (CAR, NR1I3) inverse agonist with IC50 of 0.7 uM, strongly inhibits human CAR activity via recruitment of NR corepressors and to attenuate inducer-elicited CYP2B6 expression in human primary hepatocytes. |
| PC-49716 |
DL5050
CAR agonist
|
DL5050 (DL 5050) is a potent selective agonist of human constitutive androstane receptor (CAR) with EC50 of 0.37 uM in cell-based luciferase reporter assays (Emax=3.8). |
| PC-49715 |
CITCO
CAR agonist
|
CITCO is a potent, selective agonist of orphan nuclear constitutive androstane receptor (CAR) with EC50 of 49 nM (human CAR) in CAR/SRC-1 FRET assays. |
| PC-49714 |
DL7076
CAR/Nrf2 activator
|
DL7076 (CN06) is a small molecule dual activator of the constitutive androstane receptor (CAR, NR1I3) and nuclear factor erythroid 2-related factor 2 (Nrf2) with EC50 of 8.85 and 0.72 uM, respectively. |
| PC-23985 |
CAR agonist 39
CAR agonist
|
CAR agonist 39 is a potent, selective nuclear constitutive androstane receptor (CAR, NR1I3) agonist with EC50 of 611 nM in TR-FRET assays and EC50 of 1.22 uM in CAR LBD assembly assays. |
| PC-23984 |
MI-883
CAR agonist/PXR antagonist
|
MI-883 is a potent, dual acting constitutive androstane receptor (CAR) agonist/pregnane X receptor (PXR) antagonist with EC50 of 73 nM in TR-FRET CAR coactivation assays, competes with fluorophore binding to recombinant PXR LBD with IC50 of 0.1 uM. |
