S07662 | CAR inhibitor | Probechem Biochemicals

Chemical Structure : S07662

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S07662 (S 07662)

货号: PC-49717Not For Human Use, Lab Use Only.

S07662 is a human constitutive androstane receptor (CAR, NR1I3) inverse agonist with IC50 of 0.7 uM, strongly inhibits human CAR activity via recruitment of NR corepressors and to attenuate inducer-elicited CYP2B6 expression in human primary hepatocytes.

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生物&药学活性

S07662 is a human constitutive androstane receptor (CAR, NR1I3) inverse agonist with IC50 of 0.7 uM, strongly inhibits human CAR activity via recruitment of NR corepressors and to attenuate inducer-elicited CYP2B6 expression in human primary hepatocytes.
S07662 attenuates the phenytoin- and CITCO-induced expression of CYP2B6 mRNA in human primary hepatocytes.
S07662 is a chemical tool to study the biological functions of human CAR and also as a starting point for the development of new drugs for various conditions involving the receptor.

物理化学性质&存储条件

分子量	300.38
分子式	C16H16N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(2-methylbenzofuran-3-yl)methyl]-3-(thiophen-2-ylmethyl) urea

参考文献

1. Küblbeck J, et al. Mol Pharm. 2011 Dec 5;8(6):2424-33.

S07662 (S 07662)

生物&药学活性

物理化学性质&存储条件

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S07662 (S 07662)

生物&药学活性

物理化学性质&存储条件

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