| Cat. No. |
Product Name |
Information |
| PC-23367 |
CMAP compound 5
Hedgehog inhibitor, GPR39 agonist
|
CMAP compound 5 (CMAP5) is a potent, small molecule Hedgehog pathway inhibitor with EC50 of 0.02 uM, blocks pathway signaling in a Smo-independent manner, activates GPR39. |
| PC-23366 |
CMAP compound 7
Hedgehog inhibitor, GPR39 agonist
|
CMAP compound 7 (CMAP7) is a potent, small molecule Hedgehog pathway inhibitor with EC50 of 0.01 uM, blocks pathway signaling in a Smo-independent manner, activates GPR39. |
| PC-22129 |
DS-1-38
EYA1 inhibitor
|
DS-1-38 (EYA1 inhibits DS38) is a small molecule allosteric inhibitor of EYA proteins and sonic hedgehog (SHH) signaling pathway, binds to EYA1 and inhibits EYA1 phosphatase activity. |
| PC-49551 |
Picoberin
AhR agonist
|
Picoberin is a highly potent (low picomolar) inhibitor of purmorphamine- and Sonic Hedgehog (Shh)-induced osteogenesis with IC50 of 3 pM, acts as an AhR agonist and induces the expression of AhR target genes, thereby suppressing osteoblast differentiation. |
| PC-49040 |
HhAg1.5
Hedgehog agonist
|
HhAg1.5 (SAg1.5) is a small molecule Hedgehog agonist with EC50 of 1 nM, induces cilia translocation of SMO and GLI transcription factor activation, efficiently generates expandable liver stem cells (LSCs) in vitro. |
| PC-49012 |
MDB5
Hh pathway inhibitor
|
MDB5 is a potent hedgehog (Hh) signaling pathway inhibitor, exhibits stronger inhibition of the Hh pathway and anticancer effect in vitro and vivo than GDC-0449. |
| PC-72867 |
Rhonin
RHOGDI1 inhibitor
|
Rhonin is the first small-molecule ligand of the RHO GDP-dissociation inhibitor 1 (RHOGDI1), binds to RHOGDI (Ki=2.2 uM), is an inhibitor of Hh-induced osteogenesis. |
| PC-63064 |
Cyclopamine tartrate
Hedgehog inhibitor
|
Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM. |
| PC-62852 |
BRD9526
Shh inhibitor
|
BRD9526 is a potent, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 60 nM, partially lowers Gli1 expression at concentrations of 10 uM, a useful probe of Shh signaling pathway. . |
| PC-62851 |
BRD50837
Hedgehog inhibitor
|
BRD50837 is a potent, selective, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 90 nM, partially lowers Gli1 expression at concentrations of 2 uM, a useful probe of Shh signaling pathway. . |
| PC-62182 |
Robotnikinin
Shh inhibitor
|
Robotnikinin is a small molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines, human primary keratinocytes and synthetic model of human skin. |
| PC-62179 |
HPI-1
Hedgehog inhibitor
|
HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM). |
