HPI-1 | Hedgehog inhibitor | Probechem Biochemicals

Chemical Structure : HPI-1

CAS No.: 599150-20-6

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HPI-1 (HPI1, Hedgehog Pathway Inhibitor-1)

货号: PC-62179Not For Human Use, Lab Use Only.

HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM).

规格	价格	库存
10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM).
HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression.
HPI-1 inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.

物理化学性质&存储条件

分子量	463.5
分子式	C27H29NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester

参考文献

1. Hyman JM, et al. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7.

2. Xu Y, et al. Clin Cancer Res. 2012 Mar 1;18(5):1291-302.

3. Chenna V, et al. Mol Cancer Ther. 2012 Jan;11(1):165-73.

HPI-1 (HPI1, Hedgehog Pathway Inhibitor-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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HPI-1 (HPI1, Hedgehog Pathway Inhibitor-1)

生物&药学活性

物理化学性质&存储条件

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