| Cat. No. |
Product Name |
Information |
| PC-21706 |
CC-115
DNA-PK/mTOR inhibitor
|
CC-115 is a potent, selective, dual DNA-PK and mTOR kinase inhibitor with IC50 of 13 nM and 21 nM, respectively. |
| PC-20221 |
SN38023
DNA-PK inhibitor
|
SN38023 is a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361 (Cat# PC-62995), SN38023 is metabolised to a potent DNA-PKi (IC87361) selectively in radioresistant hypoxic cells. |
| PC-20171 |
Ku-DBi 245
DNA-PK inhibitor
|
Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA. |
| PC-73106 |
AZD7648
DNA-PK inhibitor
|
AZD7648 (AZD-7648) is a potent, selective inhibitor of DNA-PK catalytic subunit (DNA-PKcs) with IC50 of 0.6 nM. |
| PC-72056 |
BAY-8400
DNA-PK inhibitor
|
BAY-8400 (BAY8400) is a highly potent, selective inhibitor of DNA-PK with biochemical IC50 of 81 nM, cellular IC50 of 69 nM (γH2AX in HT-144). |
| PC-72041 |
NU5455
DNA-PK inhibitor
|
NU5455 (NU-5455) is a potent, highly selective, oral inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity with IC50 of 8.2 nM. |
| PC-43460 |
PIK-75
p110α inhibitor
|
PIK-75 is a potent, isoform-selective p110α inhibitor with IC50 of 0.3 nM, displays >100-fold selectivity over p110β, p110δ and PI3K C2b. |
| PC-63031 |
KU-0060648
DNA-PK/PI3K inhibitor
|
KU-0060648 (KU 60648) is a potent, dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3K (IC50=4/0.5/0.1 nM for PI3Kα/β/δ). |
| PC-62996 |
IC 86621
DNA-PK inhibitor
|
IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM). |
| PC-62995 |
IC 87361
DNA-PK inhibitor
|
IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β. |
| PC-61971 |
VX-984
DNA-PK inhibitor
|
VX-984 (M9831) is a potent, selective inhibitor of DNA-PK with IC50 of 88 nM for inhibition of DNA-PKcs autophosphorylation (Ser2056) in A549 lung cancer cells, with good selectivity versus other PI3K family members. |
| PC-61970 |
SU-11752
DNA-PK inhibitor
|
SU-11752 is a potent, selective inhibitor of DNA-PK, >500-fold selectivity over PI3Kγ, inhibits DNA double-strand break repair in cells and sensitizs ionizing radiation in cancer cells. |
