Ku-DBi 245 | DNA-PK inhibitor | Probechem Biochemicals

Chemical Structure : Ku-DBi 245

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Ku-DBi 245 (Ku-DBi245)

货号: PC-20171Not For Human Use, Lab Use Only.

Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA.

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生物&药学活性

Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA.
Ku-DBi 245 does not affect the cellular viability, but potentiates the cellular effects of bleomycin through inhibition of DNA-PKcs autophosphorylation events at S2056.
Ku-DBi 245 modulates the DNA damage response in response to DNA double-strand breaks.
Ku-DBi 245 impacts the ATM DDR signaling pathway in NSCLC cells, the phosphorylation of p53 is increased by bleomycin treatment and further increased by 245 combination treatment.

物理化学性质&存储条件

分子量	582.02
分子式	C30H24ClN7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-((1-(3-(1H-tetrazol-5-yl)phenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methyl)furan-2-yl)-2-chloro-N-(3-methoxyphenyl)benzamide

参考文献

1. Mendoza-Munoz PL, et al. NAR Cancer. 2023 Feb 6;5(1):zcad003.

Ku-DBi 245 (Ku-DBi245)

生物&药学活性

物理化学性质&存储条件

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Ku-DBi 245 (Ku-DBi245)

生物&药学活性

物理化学性质&存储条件

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