KU-0060648 | DNA-PK/PI3K inhibitor | Probechem Biochemicals

Chemical Structure : KU-0060648

CAS No.: 881375-00-4

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KU-0060648 (KU0060648, KU 60648)

货号: PC-63031Not For Human Use, Lab Use Only.

KU-0060648 (KU 60648) is a potent, dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3K (IC50=4/0.5/0.1 nM for PI3Kα/β/δ).

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KU-0060648 (KU 60648) is a potent, dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3K (IC50=4/0.5/0.1 nM for PI3Kα/β/δ).
KU-0060648 shows selectively over other PI-3K-like kinases, such as ATM, ATR and mTOR.
KU-0060648 inhibits cellular DNA-PK autophosphorylation with IC50 of 19 nM (MCF7 cells) and 170 nM (SW620 cells).
KU-0060648 reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

物理化学性质&存储条件

分子量	582.719
分子式	C33H34N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide

参考文献

1. Munck JM, et al. Mol Cancer Ther. 2012 Aug;11(8):1789-98.

2. Robert F, et al. Genome Med. 2015 Aug 27;7:93.

3. Chen MB, et al. Oncotarget. 2016 Mar 29;7(13):17047-59.

4. Mao M, et al. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1244-1249.

KU-0060648 (KU0060648, KU 60648)

生物&药学活性

物理化学性质&存储条件

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KU-0060648 (KU0060648, KU 60648)

生物&药学活性

物理化学性质&存储条件

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