AZD7648 | DNA-PK inhibitor | Probechem Biochemicals

Chemical Structure : AZD7648

CAS No.: 2230820-11-6

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AZD7648 (AZD-7648)

货号: PC-73106Not For Human Use, Lab Use Only.

AZD7648 (AZD-7648) is a potent, selective inhibitor of DNA-PK catalytic subunit (DNA-PKcs) with IC50 of 0.6 nM.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

AZD7648 (AZD-7648) is a potent, selective inhibitor of DNA-PK catalytic subunit (DNA-PKcs) with IC50 of 0.6 nM.
AZD7648 displays no significant off-target activity in the protein kinome and only weak activity versus PI3Kα/γ lipid kinases.
AZD7648 increases genomic instability, resulting in cell growth inhibition and apoptosis in combination with the PARP inhibitor olaparib.
AZD7648 enhanced olaparib efficacy across a range of doses and schedules in xenograft and PDX models.
AZD7648 sensitizes tumor cells to radiotherapy and induces type I IFN-dependent durable tumor control in MC38, CT26, and B16-F10 models

物理化学性质&存储条件

分子量	380.412
分子式	C18H20N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one

参考文献

1. Goldberg FW, et al. J Med Chem. 2020 Apr 9;63(7):3461-3471.

2. Nakamura K, et al. Clin Cancer Res. 2021 Aug 1;27(15):4353-4366.

3. Fok JHL, et al. Nat Commun. 2019 Nov 7;10(1):5065.

AZD7648 (AZD-7648)

生物&药学活性

物理化学性质&存储条件

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AZD7648 (AZD-7648)

生物&药学活性

物理化学性质&存储条件

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