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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA-PK-DA-143
DA-143

Chemical Structure : DA-143

CAS No.:

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DA-143 (DA143)

货号: PC-23022Not For Human Use, Lab Use Only.

DA-143 is a potent, selective inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) with IC50 of 2.5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DA-143 is a potent, selective inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) with IC50 of 2.5 nM.
DA-143 displayed an IC50 for mTOR, PI3KΔ, and ATM at 280 nM, 106 nM and 6,594 nM respectively.
DA-143 sensitizes cancer cells to doxorubicin, blocks phosphorylation of DNA-PKcs substrates.
DA-143 prevents proper T cell activation, reduces T cell proliferation and IL2 cytokine production.

物理化学性质&存储条件

分子量 576.72
分子式 C34H32N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-morpholino-8-(8-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrazol-4-yl)dibenzo[b,d]thiophen-4-yl)-4H-chromen-4-one

参考文献

1. Waldrip ZJ, et al. Sci Rep. 2024 Aug 28;14(1):19999.

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