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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA-PK-IC 86621
IC 86621

Chemical Structure : IC 86621

CAS No.: 404009-40-1

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IC 86621 (IC86621, IC-86621)

货号: PC-62996Not For Human Use, Lab Use Only.

IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM).
IC 86621 directly inhibits the repair of DNA DSBs and consequently enhances the cytotoxicity of physical and chemical agents that induce DSBs but not other DNA lesions.

物理化学性质&存储条件

分子量 221.256
分子式 C12H15NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-hydroxy-4-morpholinophenyl)ethanone

参考文献

1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64.

2. Allen C, et al. Mol Cancer Res. 2003 Oct;1(12):913-20.

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