欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA-PK-CC-115
CC-115

Chemical Structure : CC-115

CAS No.: 1228013-15-7

加入收藏

CC-115 (CC115)

货号: PC-21706Not For Human Use, Lab Use Only.

CC-115 is a potent, selective, dual DNA-PK and mTOR kinase inhibitor with IC50 of 13 nM and 21 nM, respectively.

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CC-115 is a potent, selective, dual DNA-PK and mTOR kinase inhibitor with IC50 of 13 nM and 21 nM, respectively.
CC-115 inhibits PC-3 cells proliferation with with IC50 of 138 nM.
CC-115 blocks both mTORC1(pS6) and mTORC2(pAktS473) signaling in PC-3 cancer cells, in vitro and in vivo.
CC-115 blocks proliferation induced by CD40(+) interleukin-21 stimulation in primary CLL cells.

物理化学性质&存储条件

分子量 336.36
分子式 C16H16N8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

参考文献

1. Mortensen DS, et al. J Med Chem. 2015 Jul 23;58(14):5599-608.

2. Thijssen R, et al. Blood. 2016 Jul 28;128(4):574-83.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: