MDB5 | Hh pathway inhibitor | Probechem Biochemicals

Chemical Structure : MDB5

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MDB5 (Hh inhibitor MDB5)

货号: PC-49012Not For Human Use, Lab Use Only.

MDB5 is a potent hedgehog (Hh) signaling pathway inhibitor, exhibits stronger inhibition of the Hh pathway and anticancer effect in vitro and vivo than GDC-0449.

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生物&药学活性

MDB5 is a potent hedgehog (Hh) signaling pathway inhibitor, exhibits stronger inhibition of the Hh pathway and anticancer effect in vitro and vivo than GDC-0449.
MDB5 treatment caused a significant reduction of ALDH1, CD44 and Oct-3/4 in MIA PaCa-2 cells.
MDB5 containing nanoparticles treated group showed significant inhibition of tumor growth without loss in body weight in pancreatic tumor mouse model.
The combination of QW-296 and MDB5 exhibited stronger anticancer activity toward DU145-TXR and PC3-TXR cells and suppressed taxane-resistant (TXR) prostate cancer colony formation when compared with single-drug treatment.

物理化学性质&存储条件

分子量	568.458
分子式	C31H23Cl2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,4-Benzenedicarboxamide, 2-chloro-N1-[4-chloro-3-(2-pyridinyl)phenyl]-N4,N4-bis(2-pyridinylmethyl)-

参考文献

1. Kumar V, et al. Sci Rep. 2017 May 10;7(1):1665.

2. Yang R, et al. J Pharmacol Exp Ther. 2019 Sep;370(3):864-875.

MDB5 (Hh inhibitor MDB5)

生物&药学活性

物理化学性质&存储条件

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MDB5 (Hh inhibitor MDB5)

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物理化学性质&存储条件

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