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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Hedgehog (Hh)-CMAP compound 7
CMAP compound 7

Chemical Structure : CMAP compound 7

CAS No.: 1582736-32-0

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CMAP compound 7 (CMAP7)

货号: PC-23366Not For Human Use, Lab Use Only.

CMAP compound 7 (CMAP7) is a potent, small molecule Hedgehog pathway inhibitor with EC50 of 0.01 uM, blocks pathway signaling in a Smo-independent manner, activates GPR39.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CMAP compound 7 (CMAP7) is a potent, small molecule Hedgehog pathway inhibitor with EC50 of 0.01 uM, blocks pathway signaling in a Smo-independent manner, activates GPR39.
    CMAP compound 7 (CMAP7) inhibits Gli-activated Hh pathway signaling.
    GPR39 mRNA levelsby siRNA knockdown is sufficient to decrease the potency of CMAP7 in the Hh pathway luciferase assay.

    物理化学性质&存储条件

    分子量 604.77
    分子式 C31H40N8O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[5-[[2-[[[trans-4-[[[(3-Cyanophenyl)sulfonyl]amino]methyl]cyclohexyl]methyl]amino]-6-(2-pyridinyl)-4-pyrimidinyl]amino]pentyl]acetamide

    参考文献

    1. Bassilana F, et al. Nat Chem Biol. 2014 May;10(5):343-9.

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