Cyclopamine tartrate | Hedgehog inhibitor | Probechem Biochemicals

Chemical Structure : Cyclopamine tartrate

CAS No.: 1178510-81-0

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Cyclopamine tartrate (11-Deoxojervine tartrate)

货号: PC-63064Not For Human Use, Lab Use Only.

Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.
Cyclopamine tartrate inhibits hedgehog-dependent expression of Pax7 with IC50 of 24 nM, blocks the response of neural plate explants to recombinant Shh-N.
Cyclopamine tartrate is a useful tool in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.

物理化学性质&存储条件

分子量	973.32
分子式	C58H88N2O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,3'R,3a'S,6aS,6bS,6'S,7a'R,9R,11aS,11bR)-3',6',10,11b-tetramethyl-1,2,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11,11a,11b-octadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-3-ol (2R,3R)-2,3-dihydroxysuccinate

参考文献

1. Peukert S, et al. Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31.

2. Cooper MK, et al. Science. 1998 Jun 5;280(5369):1603-7.

3. Incardona JP, et al. Development. 1998 Sep;125(18):3553-62.

Cyclopamine tartrate (11-Deoxojervine tartrate)

生物&药学活性

物理化学性质&存储条件

参考文献

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Cyclopamine tartrate (11-Deoxojervine tartrate)

生物&药学活性

物理化学性质&存储条件

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