Robotnikinin

Chemical Structure : Robotnikinin

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货号: PC-62182Not For Human Use, Lab Use Only.

Robotnikinin is a small molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines, human primary keratinocytes and synthetic model of human skin.

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生物&药学活性

Robotnikinin is a small molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines, human primary keratinocytes and synthetic model of human skin.
Robotnikinin displays significant repression of Shh-induced Gli1/Gli2.
Robotnikinin interferes with the ability of the ShhN protein complex to relay its signal efficiently to Ptc1.

物理化学性质&存储条件

分子量	454.951
分子式	C25H27ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(4-chlorophenyl)methyl]-5,12-dioxo-2R-phenyl-1-oxa-4-azacyclododec-8E-ene-6S-acetamide

参考文献

1. Stanton BZ, et al. Nat Chem Biol. 2009 Mar;5(3):154-6.

2. Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35.

3. Peng LF, et al. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6319-25.

Robotnikinin

生物&药学活性

物理化学性质&存储条件

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Robotnikinin

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物理化学性质&存储条件

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