Rhonin

Chemical Structure : Rhonin

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货号: PC-72867Not For Human Use, Lab Use Only.

Rhonin is the first small-molecule ligand of the RHO GDP-dissociation inhibitor 1 (RHOGDI1), binds to RHOGDI (Ki=2.2 uM), is an inhibitor of Hh-induced osteogenesis.

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生物&药学活性

Rhonin is a first small-molecule ligand of the RHO GDP-dissociation inhibitor 1 (RHOGDI1), binds to RHOGDI (Ki=2.2 uM), is an inhibitor of Hh-induced osteogenesis.
Rhonin interferes with its function by disrupting the interaction between RHOGDI and RHO GTPases.
Rhonin alters the subcellular localization of RHO GTPases.
Rhonin inhibited RHOGDI1-mediated extraction of RAC1 from liposomes, Rhonin increased the levels of GTP-bound RHO GTPases, did not alter the total levels of the three RHO GTPases
Rhonin an inhibitor of Hh-induced osteogenesis, but does not efficiently target canonical Hh signaling and SMO, directly targets RHOGDI, impairs RHOGDI function.

物理化学性质&存储条件

分子量	574.431
分子式	C29H24BrN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (1S,3aS,6aR)-3-(4-bromophenyl)-5-methyl-4,6-dioxo-1-((S)-3-oxo-1-phenyl-3-(pyridin-3-yl)propyl)-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole-1-carboxylate

参考文献

1. Mohammad Akbarzadeh, et al. Angew Chem Int Ed Engl. 2022 Feb 16;e202115193.

Rhonin

生物&药学活性

物理化学性质&存储条件

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Rhonin

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物理化学性质&存储条件

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