YA8026 | hCAR agonist | Probechem Biochemicals

Chemical Structure : YA8026

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YA8026 (YA-8026)

货号: PC-28541Not For Human Use, Lab Use Only.

YA8026 is a potent, selective activator / agonist of human constitutive androstane receptor (hCAR) with EC50 of 0.5 uM and Emax of 170%, shows favorable selectivity over human pregnane X receptor (hPXR) and related nuclear receptors.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

YA8026 is a potent, selective activator / agonist of human constitutive androstane receptor (hCAR) with EC50 of 0.5 uM and Emax of 170%, shows favorable selectivity over human pregnane X receptor (hPXR) and related nuclear receptors.
YA8026 induces CYP2B6 and promotes hCAR nuclear translocation in human primary hepatocytes.
YA8026 exhibits minimal kinase inhibition across a panel of 280 kinases.
YA8026 exhibits favorable selectivity, stability, and safety characteristics.

物理化学性质&存储条件

分子量	400.53
分子式	C25H28N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-N-(3-phenylpropyl)-5,6,7,8-tetrahydroquinazolin-4-amine

参考文献

1. Ai Y, et al. Eur J Med Chem. 2026 Oct 13;321(Pt 2):119414.

YA8026 (YA-8026)

生物&药学活性

物理化学性质&存储条件

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YA8026 (YA-8026)

生物&药学活性

物理化学性质&存储条件

参考文献

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