DCPT1061 | Type I PRMTs inhibitor | Probechem Biochemicals

Chemical Structure : DCPT1061

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DCPT1061 (DCPT-1061)

货号: PC-23080Not For Human Use, Lab Use Only.

DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes.

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生物&药学活性

DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes.
DCPT1061 significantly induced a dose-dependent inhibition of cell proliferation in ccRCC cell lines including 786-O, A498, ACHN, and Caki-1 (IC50=0.5-2.8 uM), induced G1 cycle arrest in ccRCC cells.
CPT1061 inhibited AKT and RB phosphorylation in Caki-1 cells.
Combinational treatment of DCPT1061 and sunitinib exhibited a striking anticancer effect in ccRCC.

物理化学性质&存储条件

分子量	339.26
分子式	C17H20Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-[[2-(2,3-Dichlorophenoxy)phenyl]methyl]-N1,N2-dimethyl-1,2-ethanediamine

参考文献

1. Wang J, et al. Theranostics. 2021 Mar 12;11(11):5387-5403.

DCPT1061 (DCPT-1061)

生物&药学活性

物理化学性质&存储条件

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DCPT1061 (DCPT-1061)

生物&药学活性

物理化学性质&存储条件

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