| Cat. No. |
Product Name |
Information |
| PC-24531 |
CG3-46
CBX2 inhibitor
|
CG3-46 is a specific nonpeptide small molecule CBX2 inhibitor, inhibits the interaction between CBX2 and H3K27me3 with IC50 of 15.4 μM and 14.6 μM in NanoBRET and NanoBiT assays, respectively. |
| PC-24527 |
HH2853
EZH1/2 inhibitor
|
HH2853 is a novel potent dual EZH1/2 inhibitor that effectively inhibit the catalytic activity of wild-type EZH2 and mutated forms (A677G, Y641F, Y641N, and Y641C) with IC50 of 3.75, 2.21, 2.65, and 2.62 nM respectively, synchronously suppresses EZH1 activity with IC50 of 9.26 nM. |
| PC-24375 |
CM112
PRMT1 degrader
|
CM112 is a potent, selective PRMT1 degrader designed by tethering adamantane to MS023 via a 5-PEG linker, has DC50 of 0.83 uM in MCF-7 cells. |
| PC-24337 |
iZMYND8-34
ZMYND8 inhibitor
|
iZMYND8-34 is a small molecule inhibitor of histone reader zinc finger MYND-type containing 8 (ZMYND8), inhibits ZMYND8 histone recognition, effectively blocks neuroendocrine prostate cancer (NEPC) development. |
| PC-24327 |
NSD3 inhibitor A8
NSD3 inhibitor
|
NSD3 inhibitor A8 is a potent small molecule inhibitor of nuclear receptor-binding SET domain protein 3 (NSD3) with IC50 of 0.7 uM, inhibits NSD1 and NSD2 with IC50 of 1.5 uM and 0.9 uM respectively. |
| PC-24292 |
Dual CARM1-IKZF3 inhibitor 074
CARM1/IKZF3 inhibitor
|
Dual CARM1-IKZF3 inhibitor 074 is a compound composed of the CARM1 inhibitor EZM2302, linked to pomalidomide, increases CRBN-dependent IKZF1, IKZF3, ZFP91, and FGD3 protein degradation, inhibits CRAM1 with IC50 of 2 nM. |
| PC-24113 |
Balomenib
Menin-KMT2A inhibitor
|
Balomenib (Balamenib, ZE63-0302) is an oral small molecule inhibitor of the menin-KMT2A interaction. |
| PC-24105 |
YTHDF2 Inhibitor CK-75
YTHDF2 inhibitor
|
YTHDF2 Inhibitor CK-75 is a specific small molecule inhibitor of YTHDF2, potentially binds to a small hydrophobic pocket on the YTH domain (KD=26.2 uM), potently inhibits the protein-RNA interaction of YTHDF2. |
| PC-24018 |
STC-15
METTL3 inhibitor
|
STC-15 is a small molecule, orally active inhibitor of RNA methyltransferase METTL3, restrains cancer growth and induces anti-cancer immunity. |
| PC-24065 |
MS9024
DNMT1 degrader
|
MS9024 is a potent, selective PROTAC degrader of DNA methyltransferase 1 (DNMT1) with DC50 of 40 nM in HCT116 cells, Dmax=89%. |
| PC-24017 |
STM3006
METTL3 inhibitor
|
STM3006 is a potent, selective second-generation METTL3 inhibitor with IC50 of 5 nM, stimulates a cell-intrinsic interferon response through dsRNA formation and promotes antitumor immunity. |
| PC-23957 |
DDD1870799
RNMT inhibitor
|
DDD1870799 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 2.5 uM. |
