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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)

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Cat. No. Product Name Information
PC-45489

PFI-2 hydrochloride

SETD7 inhibitor

PFI-2 ((R)-PFI-2) hydrochloride is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively.
PC-45488

PFI-2

SETD7 inhibitor

PFI-2 ((R)-PFI-2) is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively.
PC-25006

SHR2554

EZH2 inhibitor

Zeprumetostat (SHR2554) is a potent, highly selective EZH2 inhibitor, specifically inhibits both wild-type (IC50=0.87 nM) and mutant (EZH2(Y641F), IC50=2.68 nM) EZH2 methyltransferase activity with similar potencies.
PC-24896

KMT9 inhibitor 7b

KMT9 inhibitor

KMT9 inhibitor 7b is a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM.
PC-24895

KMT9 inhibitor 8

KMT9 inhibitor

KMT9 inhibitor 8 is the ethyl ester prodrug of KMT9 inhibitor 7b, a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM.
PC-24714

PRMT5 inhibitor 16-19F

PRMT5-MTA inhibitor

PRMT5 inhibitor 16-19F is a specific synthetic inhibitor of the PRMT5-MTA complex with SPR KD of 2.54, 0.36 and 0.15 uM against apo-PRMT5:MEP50 and SAM- and MTA-bound PRMT5:MEP50 complexes respectively, selectively inhibits MTAP-deleted cancer cell growth.
PC-24609

BCOR-PCGF1 inhibitor iBP

PRC1.1 inhibitor

BCOR-PCGF1 inhibitor iBP is a selective PRC1.1 inhibitor, specifically inhibits the interaction between BCOR and PCGF1 with IC50 of 12.21 uM in AlphaScreen assays, limits H2AK119ub1 activity and activates Wnt signaling pathway.
PC-24531

CG3-46

CBX2 inhibitor

CG3-46 is a specific nonpeptide small molecule CBX2 inhibitor, inhibits the interaction between CBX2 and H3K27me3 with IC50 of 15.4 μM and 14.6 μM in NanoBRET and NanoBiT assays, respectively.
PC-24527

HH2853

EZH1/2 inhibitor

HH2853 is a novel potent dual EZH1/2 inhibitor that effectively inhibit the catalytic activity of wild-type EZH2 and mutated forms (A677G, Y641F, Y641N, and Y641C) with IC50 of 3.75, 2.21, 2.65, and 2.62 nM respectively, synchronously suppresses EZH1 activity with IC50 of 9.26 nM.
PC-24375

CM112

PRMT1 degrader

CM112 is a potent, selective PRMT1 degrader designed by tethering adamantane to MS023 via a 5-PEG linker, has DC50 of 0.83 uM in MCF-7 cells.
PC-24337

iZMYND8-34

ZMYND8 inhibitor

iZMYND8-34 is a small molecule inhibitor of histone reader zinc finger MYND-type containing 8 (ZMYND8), inhibits ZMYND8 histone recognition, effectively blocks neuroendocrine prostate cancer (NEPC) development.
PC-24327

NSD3 inhibitor A8

NSD3 inhibitor

NSD3 inhibitor A8 is a potent small molecule inhibitor of nuclear receptor-binding SET domain protein 3 (NSD3) with IC50 of 0.7 uM, inhibits NSD1 and NSD2 with IC50 of 1.5 uM and 0.9 uM respectively.

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