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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)

Request The Product List ofHistone Methyltransferase (HMTase) Histone Methyltransferase (HMTase)

Cat. No. Product Name Information
PC-23618

AS-254s

ASH1L inhibitor

AS-254s is a highly potent and selective histone lysine methyltransferase ASH1L (absent, small, or homeotic-like 1) inhibitor with IC50 of 94 nM in FP assays, binds to the catalytic SET domain of ASH1L with ITC Kd of 179 nM.
PC-23492

ASH1L inhibitor AS-99 TFA

ASH1L inhibitor

ASH1L inhibitor AS-99 TFA (AS99) is a first-in-class, potent, selective inhibitor of ASH1L histone methyltransferase with IC50 of 0.79 uM.
PC-23491

ASH1L inhibitor AS-85 hydrochloride

ASH1L inhibitor

ASH1L inhibitor AS-85 hydrochloride (AS85) is a first-in-class, potent, selective inhibitor of ASH1L histone methyltransferase with IC50 of 0.6 uM.
PC-23490

ASH1L inhibitor AS-85

ASH1L inhibitor

ASH1L inhibitor AS-85 (AS85) is a first-in-class, potent, selective inhibitor of ASH1L histone methyltransferase with IC50 of 0.6 uM.
PC-23344

BR0063

PRC2 inhibitor

BR0063 is a potent, selective EED-directed allosteric inhibitor of polycomb repressive complex 2 (PRC2), efficiently blocks the interaction of the EED subunit with H3K27me3 (EC50=5.9 nM), which led to the marked inhibition of cellular PRC2 activity.
PC-23238

YD1342

PRMT4 inhibitor

YD1342 is the in-vivo active prodrug of YD1130, a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM).
PC-23237

YD1130

PRMT4 inhibitor

YD1130 is a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM) over a panel of 38 methyltransferases, including the other PRMTs.
PC-23204

SETD8 inhibitor C23

SETD8 inhibitor

SETD8 inhibitor C23 is a novel chemical inhibitor of SETD8, inhibits H4K20 methylation, inhibits IR-induced 53BP1 foci.
PC-23098

Igermetostat

EZH2 inhibitor

Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2.
PC-23080

DCPT1061

Type I PRMTs inhibitor

DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes.
PC-23079

MS167

PRMT6 inhibitor

MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM.
PC-23078

MS117

PRMT6 inhibitor

MS117 is a potent, selective and cell-active covalent PRMT6 inhibitor with Ki of 16 nM and IC50 of 18 nM.

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