KMT9 inhibitor 8

Chemical Structure : KMT9 inhibitor 8

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货号: PC-24895Not For Human Use, Lab Use Only.

KMT9 inhibitor 8 is the ethyl ester prodrug of KMT9 inhibitor 7b, a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM.

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生物&药学活性

KMT9 inhibitor 8 is the ethyl ester prodrug of KMT9 inhibitor 7b, a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM.
KMT9 inhibitor 8 exhibits cellular target engagement and reduces cellular levels of histone H4K12 monomethylation.
KMT9 inhibitor 8 specifically blocks proliferation of colon cancer cells.
KMT9 inhibitor 8 is a tool compound to investigate the function of KMT9 in cells.

物理化学性质&存储条件

分子量	712.26
分子式	C36H47ClFN7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl (S)-2-amino-4-((3-((4-(4-chlorophenoxy)-3-fluorophenethyl)amino)propyl) (((1R,2R,3S,4R)-2,3-dihydroxy-4-(4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl) cyclopentyl)methyl)amino)butanoate

参考文献

1. Wang S, et al. J Med Chem. 2025 Jun 17. doi: 10.1021/acs.jmedchem.4c02953.

KMT9 inhibitor 8

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物理化学性质&存储条件

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KMT9 inhibitor 8

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