| Cat. No. |
Product Name |
Information |
| PC-21038 |
KTX-1001
NSD2 inhibitor
|
Gintemetostat (KTX-1001) is a potent, selective histone methyltransferase NSD2 (WHSC1, MMSET) inhibitor targeting the catalytic SET domain with IC50 of 2.32 nM. |
| PC-21013 |
EML1219
PRMT9 inhibitor
|
EML1219 is a selective small molecule inhibitor of protein arginine methyltransferase isoform PRMT9 with IC50 of 0.2 uM. |
| PC-21012 |
EML734
PRMT7/9 inhibitor
|
EML734 is a selective small molecule inhibitor of protein arginine methyltransferase isoforms, PRMT7 and PRMT9 with IC50 of 0.32 and 0.89 uM, respectively. |
| PC-20906 |
EPIC-0307
PRADX-EZH2 inhibitor
|
EPIC-0307 is a selective small-molecule inhibitor of PRADX-EZH2 interaction, inhibits GBM cell lines with IC50 of 12.13-17.69 uM, enhances temozolomide (TMZ) sensitivity to glioblastoma. |
| PC-20858 |
BBDDL2059
EZH2 inhibitor
|
BBDDL2059 (BBDDL 2059) is a potent, selective and covalent inhibitor of EZH2 with IC50 of 1.5 nM (EZH2-Y641F), targeting the Cys663 of EZH2. |
| PC-20857 |
CPI-1328
EZH2 inhibitor
|
CPI-1328 is a highly potent, selective EZH2 inhibitor with sub-pM binding affinitiy (Ki=63 fM). |
| PC-20832 |
SETDB1 activator (R,R)-59
SETDB1 activator
|
(R,R)-59 is a small-molecule ligand activator for methyltransferase SETDB1 Triple Tudor Domain (3TD reader domain) with binding IC50 of 1.2 uM in TR-FRET assays, specifically promotes in vitro SETDB1-mediated methylation of lysine 64 of protein kinase Akt1. |
| PC-20645 |
HKMTI-1-005
G9a/GLP/EZH2 inhibitor
|
HKMTI-1-005 is a potent, substrate-competitive dual inhibitor of EZH2 and the closely related G9a/GLP H3K9 methyltransferases with IC50 of 0.1 uM (EHMT2). |
| PC-20564 |
M-808
menin-MLL inhibitor
|
M-808 (M808) is a highly potent, selective and covalent inhibitor of menin-MLL interaction with binding IC50 of 2.6 nM, forms a covalent bond with Cys329 in menin. |
| PC-20553 |
Igf2bp1 inhibitor 7773
Igf2bp1 inhibitor
|
Igf2bp1 inhibitor 7773 is a specific small molecule inhibitor of Igf2bp1, binds to RNA binding domains of Igf2bp1, inhibits Igf2bp1 binding of Kras 6 RNA with IC50 of 30 uM. |
| PC-20514 |
Pociredir
PRC2 inhibitor
|
Pociredir (FTX-6058) is an oral, allosteric polycomb repressive complex 2 (PRC2) inhibitor, targeting the embryonic ectoderm development (EED) subunit of PRC2. |
| PC-20135 |
UZH1a
METTL3 inhibitor
|
UZH1a is a potent, selective and cell‐permeable inhibitor of METTL3 with IC50 of 0.28 uM, 100-fold more potent than enantiomer UZH1b. |
