G9a inhibitor E72 | G9a/GLP inhibitor Probechem Biochemicals

Chemical Structure : G9a inhibitor E72

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G9a inhibitor E72 (E72)

货号: PC-63022Not For Human Use, Lab Use Only.

G9a inhibitor E72 (E-72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2.

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生物&药学活性

G9a inhibitor E72 (E72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2.
G9a inhibitor E72 reactivates K-ras-mediated epigenetic silencing of the proapoptotic Fas gene in NIH 3T3 cells, with much reduced cell cytotoxicity compared with BIX-01294.

物理化学性质&存储条件

分子量	544.789
分子式	C29H52N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((5-aminopentyl)oxy)-N4-(1-(5-aminopentyl)piperidin-4-yl)-N2-(3-(dimethylamino)propyl)-6-methoxyquinazoline-2,4-diamine

参考文献

1. Chang Y, et al. J Mol Biol. 2010 Jul 2;400(1):1-7.

G9a inhibitor E72 (E72)

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物理化学性质&存储条件

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G9a inhibitor E72 (E72)

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物理化学性质&存储条件

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