MI-2-2 |CAS:1454920-20-7 Probechem Biochemicals

Chemical Structure : MI-2-2

CAS No.: 1454920-20-7

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MI-2-2 (menin-MLL inhibitor)

货号: PC-62485Not For Human Use, Lab Use Only.

MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3680	In stock
25 mg	￥5580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
MI-2-2 inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2.
MI-2-2 suppresses growth of MLL-AF9–transformed BMCs.
MI-2-2 causes MV4:11 cells growth inhibition of with GI50 of 3 uM.

物理化学性质&存储条件

分子量	415.497
分子式	C17H20F3N5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine

参考文献

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

2. Shi A, et al. Blood. 2012 Nov 29;120(23):4461-9.

MI-2-2 (menin-MLL inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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MI-2-2 (menin-MLL inhibitor)

生物&药学活性

物理化学性质&存储条件

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