| Cat. No. |
Product Name |
Information |
| PC-35041 |
TBBD
CARM1 inhibitor
|
TBBD (Ellagic acid) is a specific inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) that selectively inhibits methylation at arginine 17 of histone H3 (H3R17). |
| PC-63547 |
TP-064N
TP-064 control
|
TP-064N is a negative control chemical of TP-064, which is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM.. |
| PC-63546 |
TP-064
PRMT4 inhibitor
|
TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) for PRMT4 over other PRMTs. |
| PC-63538 |
T1551
PRMT5 inhibitor
|
T1551 is a novel, potent and specific PRMT5 inhibitor with IC50 of 34.1 uM, exhibits anti-proliferation on A549 cell with IC50 of 11.2 uM. |
| PC-63461 |
LLY-283
PRMT5 inhibitor
|
LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM. |
| PC-63250 |
BAY-6035
|
BAY-6035 is a potent, peptide-competitive inhibitor of histone methyltransferase SMYD3, inhibits in vitro methylation of MEKK2 peptide with IC50 of 88 nM, >100-fold selectivity over other HMTases. |
| PC-43301 |
EPZ020411 hydrochloride
PRMT6 inhibitor
|
EPZ020411 hydrochloride is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
| PC-43300 |
EPZ020411
PRMT6 inhibitor
|
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
| PC-43259 |
GSK503
EZH2 inhibitor
|
GSK503 is a potent, specific EZH2 methyltransferase inhibitor that inhibits the methyltransferase activity of WT and mutant EZH2 with similar potency (Ki app=3-27 nM). |
| PC-43184 |
CARM1-IN-7g
CARM1 inhibitor
|
CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7). |
| PC-43165 |
EPZ015666
PRMT5 inhibitor
|
EPZ015666 (GSK3235025) is a potent, selective, orally available inhibitor of PRMT5 with Ki/IC50 of 5/22 nM, displays broad selectivity against a panel of other histone methyltransferases. |
| PC-63229 |
PJ-68
PRMT5 inhibitor
|
PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8). |
