DS-437 |CAS:1674364-87-4 Probechem Biochemicals

Chemical Structure : DS-437

CAS No.: 1674364-87-4

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DS-437 (DS437;DS 437)

货号: PC-35043Not For Human Use, Lab Use Only.

DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases.

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5 mg	￥1580	In stock
10 mg	￥2580	In stock
25 mg	￥3980	In stock
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生物&药学活性

DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases.
DS-437 inhibits methylation of full-length histone 4 by PRMT5-MEP50 with an IC50 of 37 ± 1.2 μM in a biochemical assay.
DS-437 inhibits symmetrical dimethylation of PRMT5 substrates in cells.

物理化学性质&存储条件

分子量	397.454
分子式	C15H23N7O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[2-[[(2S,3R,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea

参考文献

1. Smil D, et al. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12.

DS-437 (DS437;DS 437)

生物&药学活性

物理化学性质&存储条件

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DS-437 (DS437;DS 437)

生物&药学活性

物理化学性质&存储条件

参考文献

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