TP-064 | PRMT4 inhibitor | Probechem Biochemicals

Chemical Structure : TP-064

CAS No.: 2080306-20-1

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TP-064 (TP064)

货号: PC-63546Not For Human Use, Lab Use Only.

TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) for PRMT4 over other PRMTs.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM.
TP-064 shows high selectivity (>100-fold) for PRMT4 over other PRMTs.
TP-064 reduces dimethylation of BAF155 (IC50=340±30 nM) and MED12 (IC50=43±10 nM) in a dose-dependent manner in cell-baed assays.
TP-064 inhibits the proliferation of a subset of multiple myeloma cell lines (NCI-H929, RPMI8226, Cell IC50 of 379 and 886 nM, respectively) with affected cells arrested in G1 phase of the cell cycle, but has no effect on acute myeloid leukemia, colon cancer, or lung cancer cell lines.

物理化学性质&存储条件

分子量	458.606
分子式	C28H34N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	250 mM in DMSO (114.65 mg/mL)
Chemical Name/SMILES	N-methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide

参考文献

1. Nakayama K, et al. Oncotarget. 2018 Apr 6;9(26):18480-18493.

TP-064 (TP064)

生物&药学活性

物理化学性质&存储条件

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TP-064 (TP064)

生物&药学活性

物理化学性质&存储条件

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