MAK683 |CAS:1951408-58-4 Probechem Biochemicals

Chemical Structure : MAK683

CAS No.: 1951408-58-4

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MAK683 (MAK-683;MAK683)

货号: PC-35591Not For Human Use, Lab Use Only.

MAK683 (MAK-683) is a potent and selective EED inhibitor with biochemical IC50 of 9 nM, and allosteric inhibitor of polycomb repressive complex 2 (PRC2), selectively binds to the domain of EED that interacts with H3K27me3).

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
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100 mg		Get quote

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生物&药学活性

MAK683 (MAK-683) is a potent and selective EED inhibitor with biochemical IC50 of 9 nM, and allosteric inhibitor of polycomb repressive complex 2 (PRC2), selectively binds to the domain of EED that interacts with H3K27me3).
MAK683 leads to a conformational change in the EED H3K27me3-binding pocket and prevents the interaction of EED with the histone methyltransferase enhancer zeste homolog 2 (EZH2).
MAK683 inhibits tumor cell proliferation in EZH2-mutated and PRC2-dependent cancer cells.

物理化学性质&存储条件

分子量	376.39
分子式	C20H17FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

参考文献

1. Huang Y, et al. J Med Chem. 2022 Apr 14;65(7):5317-5333.

MAK683 (MAK-683;MAK683)

生物&药学活性

物理化学性质&存储条件

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MAK683 (MAK-683;MAK683)

生物&药学活性

物理化学性质&存储条件

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