| Cat. No. |
Product Name |
Information |
| PC-24113 |
Balomenib
Menin-KMT2A inhibitor
|
Balomenib (Balamenib, ZE63-0302) is an oral small molecule inhibitor of the menin-KMT2A interaction. |
| PC-24105 |
YTHDF2 Inhibitor CK-75
YTHDF2 inhibitor
|
YTHDF2 Inhibitor CK-75 is a specific small molecule inhibitor of YTHDF2, potentially binds to a small hydrophobic pocket on the YTH domain (KD=26.2 uM), potently inhibits the protein-RNA interaction of YTHDF2. |
| PC-24018 |
STC-15
METTL3 inhibitor
|
STC-15 is a small molecule, orally active inhibitor of RNA methyltransferase METTL3, restrains cancer growth and induces anti-cancer immunity. |
| PC-24065 |
MS9024
DNMT1 degrader
|
MS9024 is a potent, selective PROTAC degrader of DNA methyltransferase 1 (DNMT1) with DC50 of 40 nM in HCT116 cells, Dmax=89%. |
| PC-24017 |
STM3006
METTL3 inhibitor
|
STM3006 is a potent, selective second-generation METTL3 inhibitor with IC50 of 5 nM, stimulates a cell-intrinsic interferon response through dsRNA formation and promotes antitumor immunity. |
| PC-24016 |
EP652
METTL3 inhibitor
|
EP652 is a potent, selective and in vivo active inhibitor of RNA methyltransferase METTL3 with IC50 of 2 nM (METTL3/14) in SPA primary assays. |
| PC-23957 |
DDD1870799
RNMT inhibitor
|
DDD1870799 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 2.5 uM. |
| PC-23956 |
DDD1060606
RNMT inhibitor
|
DDD1060606 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 1.6 uM. |
| PC-23905 |
CSV0C018875
G9a inhibitor
|
CSV0C018875 is a cell active quinoline based G9a inhibitor with IC50 of 67.02 uM. |
| PC-23904 |
HKMTI-1-248
G9a/GLP inhibitor
|
HKMTI-1-248 is a potent and selective G9a/GLP inhibitor with IC50 of 13 nM (G9a), equipotent against G9a and GLP (G9a-like protein, EHMT1). |
| PC-23903 |
EPZ035544
G9a/GLP inhibitor
|
EPZ035544 is a potent inhibitor of histone methyltransferase G9a/GLP with IC50 of 10 nM/<100 nM respectively. |
| PC-23902 |
ZZM-1220
G9a/GLP inhibitor
|
ZZM-1220 is a potent, selective G9a/GLP covalent inhibitor with IC50 of 458/924 nM respectively. |
