MI-538 |CAS:1857417-10-7 Probechem Biochemicals

Chemical Structure : MI-538

CAS No.: 1857417-10-7

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MI-538 (MI538;MI 538)

货号: PC-45727Not For Human Use, Lab Use Only.

MI-538 is potent and selective menin-MLL interaction inhibitor (IC50=21 nM).

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5 mg	￥1780	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MI-538 is potent and selective menin-MLL interaction inhibitor (IC50=21 nM).
MI-538 shows the most potent binding affinity to menin (Kd = 6.5 nM) obtained for small molecule menin–MLL inhibitor reported to date.
MI-538 exhibits significantly increased activity, selectivity, polarity and pharmacokinetic profile over MI-136 and demonstrates a pronounced effect in a mouse model of MLL leukemia.

物理化学性质&存储条件

分子量	566.6006
分子式	C27H25F3N8OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO; Need ultrasonic and warming
Chemical Name/SMILES	1H-Indole-2-carbonitrile, 6-hydroxy-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-

参考文献

1. Borkin D, et al. J Med Chem. 2016 Feb 11;59(3):892-913.

MI-538 (MI538;MI 538)

生物&药学活性

物理化学性质&存储条件

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MI-538 (MI538;MI 538)

生物&药学活性

物理化学性质&存储条件

参考文献

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