EED226 |CAS:2083627-02-3 Probechem Biochemicals

Chemical Structure : EED226

CAS No.: 2083627-02-3

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EED226 (EED 226;EED-226)

货号: PC-42321Not For Human Use, Lab Use Only.

EED226 (EED 226) is a potent, selective, orally bioavailable PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED (IC50=22 nM).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

EED226 (EED 226) is a potent, selective, orally bioavailable PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED (IC50=22 nM).
EED226 shows remarkable selectivity over 21 other PRMTs, with one exception EZH1.
EED226 potently reduces global H3K27Me3 mark in cells and demonstrates selectively cell killing effects in cells carrying a heterozygous Y641N mutation.
EED226 induces robust and sustained tumor regression in EZH2MUT pre-clinical DLBCL model.

物理化学性质&存储条件

分子量	369.3977
分子式	C17H15N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-(2-furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-

参考文献

1. Qi W, et al. Nat Chem Biol. 2017 Apr;13(4):381-388.

2. Huang Y, et al. J Med Chem. 2017 Mar 23;60(6):2215-2226.

EED226 (EED 226;EED-226)

生物&药学活性

物理化学性质&存储条件

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EED226 (EED 226;EED-226)

生物&药学活性

物理化学性质&存储条件

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