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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-EPZ031686
EPZ031686

Chemical Structure : EPZ031686

CAS No.: 2095161-11-6

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EPZ031686 (EPZ-031686, EPZ 031686)

货号: PC-45608Not For Human Use, Lab Use Only.

EPZ031686 (EPZ 031686) is a potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM, Cell IC50= 36 nM).

规格 价格 库存 数量
5 mg ￥2780 In stock
10 mg ￥4580 In stock
25 mg ￥7880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EPZ031686 (EPZ 031686) is a potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM, Cell IC50= 36 nM).
EPZ031686 displays <30% inhibition against 16 histone methyltransferase targets at 10 uM.
EPZ031686 shows good oral bioavailability and more favorable ADME profile than EPZ030456; orally active.

物理化学性质&存储条件

分子量 591.0858
分子式 C26H34ClF3N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 5.9 mg/mL
Chemical Name/SMILES

1H-Indole-5-carboxamide, 6-chloro-2,3-dihydro-2-oxo-N-[(3-endo)-8-[[[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl]sulfonyl]-8-azabicyclo[3.2.1]oct-3-yl]-

参考文献

1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8.

2. Rajajeyabalachandran G, et al. Expert Opin Ther Targets. 2017 Feb;21(2):145-157.

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