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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-MI-463
MI-463

Chemical Structure : MI-463

CAS No.: 1628317-18-9

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MI-463 (MI463;MI 463)

货号: PC-45726Not For Human Use, Lab Use Only.

MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM).

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5 mg ￥1480 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM).
MI-463 shows profound effects in MLL leukemia cells and substantial survival benefit in mouse models of MLL leukemia.

物理化学性质&存储条件

分子量 484.5398
分子式 C24H23F3N6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-

参考文献

1. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.

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