| Cat. No. |
Product Name |
Information |
| PC-21346 |
MS1262
G9a/GLP inhibitor
|
MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively. |
| PC-21301 |
NSUN2 inhibitor MY-1B
NSUN2 inhibitor
|
NSUN2 inhibitor MY-1B is specific, covalent inhibitor of RNA methyltransferase NSUN2 (IC50=1.3 uM) that stereoselectively react with the catalytic C271, has IC50 of 2.4 uM in RNA methylation assays. |
| PC-21078 |
METTL3 inhibitor 54
METTL3 inhibitor
|
METTL3 inhibitor 54 is a potent, selective inhibitor of m6A-RNA writer enzyme methyltransferase-like 3 (METTL3) with IC50 of 54 nM for METTL3/METTL14 in HTRF assays. |
| PC-21038 |
KTX-1001
NSD2 inhibitor
|
KTX-1001 is a potent, selective histone methyltransferase NSD2 (WHSC1, MMSET) inhibitor targeting the catalytic SET domain. |
| PC-21012 |
EML734
PRMT7/9 inhibitor
|
EML734 is a selective small molecule inhibitor of protein arginine methyltransferase isoforms, PRMT7 and PRMT9 with IC50 of 0.32 and 0.89 uM, respectively. |
| PC-20645 |
HKMTI-1-005
G9a/GLP/EZH2 inhibitor
|
HKMTI-1-005 is a potent, substrate-competitive dual inhibitor of EZH2 and the closely related G9a/GLP H3K9 methyltransferases with IC50 of 0.1 uM (EHMT2). |
| PC-20135 |
UZH1a
METTL3 inhibitor
|
UZH1a is a potent, selective and cell‐permeable inhibitor of METTL3 with IC50 of 0.28 uM, 100-fold more potent than enantiomer UZH1b. |
| PC-20124 |
DC-PRC2in-01
EZH2-EED inhibitor
|
DC-PRC2in-01 is a small molecule PRC2 inhibitor targeting EZH2-EED interaction with affinity Kd of 4.56 uM, decreases global H3K27me3 levels in cancer cells. |
| PC-20002 |
UNC2327
PRMT3 inhibitor
|
UNC2327 (UNC-2327) is a potent, allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 of 230 nM. |
| PC-49859 |
DS-1594a
Menin-MLL1 inhibitor
|
DS-1594a (Emilumenib) is a highly potent Menin-MLL1 inhibitor with IC50 of 1.4 nM in cell-free AlphaLISA assays, displays selective growth inhibition against AML and ALL cells with MLL1-r or NPM1c. |
| PC-49814 |
SMYD3 inhibitor 49
SMYD3 inhibitor
|
SMYD3 inhibitor 49 is a potent and selective SMYD3 inhibitor with IC50 of 6.3 and 44 nM in biochemical and cellular MEKK2me assays, respectively. |
| PC-49813 |
EM127
SMYD3 inhibitor
|
EM127 is a potent, site-specific covalent, second-generation inhibitor of SMYD3 methyltransferase. |
