MS3-123

Chemical Structure : MS3-123

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货号: PC-27104Not For Human Use, Lab Use Only.

MS3-123 is a highly potent, selective and covalent inhibitor of PRMT1 with IC50 of 11.4 nM, targeting the unique Cys119 within the SAM-binding pocket of PRMT1.

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生物&药学活性

MS3-123 is a highly potent, selective and covalent inhibitor of PRMT1 with IC50 of 11.4 nM, targeting the unique Cys119 within the SAM-binding pocket of PRMT1.
MS3-123 shows 17-96-fold selectivity against other type I PRMTs subfamily and >439-fold selectivity against type II PRMT5.
MS3-123 selectively engages Cys119, inhibiting PRMT1 activity at both enzymatic and cellular levels.
MS3-123 suppressed breast cancer cell proliferation, migration, invasion, induced cell cycle arrest and apoptosis, and impaired tumor growth in vivo in the MDA-MB-231-xenograft model.

物理化学性质&存储条件

分子量	455.80
分子式	C15H24BrClN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5-bromo-4-((4-(dimethylamino)piperidin-1-yl)sulfonyl)-1-methyl-1H-pyrrol-2-yl)methyl)-2-chloroacetamide

参考文献

1. Shao M, et al. J Med Chem. 2026 Jun 17. doi: 10.1021/acs.jmedchem.6c00262.

MS3-123

生物&药学活性

物理化学性质&存储条件

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MS3-123

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物理化学性质&存储条件

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