TNG917 (TNG-917)

Chemical Structure : TNG917

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货号: PC-26996Not For Human Use, Lab Use Only.

TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases.

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100 mg		Get quote

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生物&药学活性

TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases.
TNG917 relieved H3K9-mediated repression, restored interferon-stimulated gene expression, and triggered secretion of T-cell chemoattractant cytokines, including CXCL10, in cancer cells.
TNG917 monotherapy led to marked tumor growth inhibition, while combination with anti-PD1 therapy produced complete, durable regressions and established protective immune memory in both syngeneic and humanized mouse models.

物理化学性质&存储条件

分子量	369.44
分子式	C20H24FN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Pyrimidinediamine, N2-[6-fluoro-2,3-dihydro-7-(2,5,6,7-tetrahydro-1H-azepin-4-yl)-5-benzofuranyl]-N4,6-dimethyl-

参考文献

1. Lu AZ, et al. Cancer Res. 2026 Jun 10. doi: 10.1158/0008-5472.CAN-25-4720.

TNG917 (TNG-917)

生物&药学活性

物理化学性质&存储条件

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TNG917 (TNG-917)

生物&药学活性

物理化学性质&存储条件

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