| Cat. No. |
Product Name |
Information |
| PC-35850 |
LEM-14-1189
NSD2 inhibitor
|
LEM-14-1189 is a LEM-14 derivative that differentially inhibits the NSDs with in vitro IC50 of 418 μM (NSD1), IC50 of 111 μM (NSD2) and IC50 of 60 μM (NSD3). |
| PC-35849 |
LEM-14
NSD2 inhibitor
|
LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3. |
| PC-35846 |
VinSpinIn
Spin1 inhibitor
|
VinSpinIn is a potent, cell active chemical probe for the Spin family protein with Kd of 10-130 nM for across the family, displays >300-fold selectivity over a panel of methyltransferases. |
| PC-35810 |
EPZ020411 dihydrochloride
PRMT6 inhibitor
|
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
| PC-44245 |
AZ505
SMYD2 inhibitor
|
AZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM, displays >600-fold against other histone methyltransferases, such as SMYD3 and EZH2. |
| PC-35634 |
OTS186935
SUV39H2 inhibitor
|
OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM. |
| PC-35633 |
OTS193320
SUV39H2 inhibitor
|
OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM. |
| PC-35608 |
Furamidine dihydrochloride
Tdp1 inhibitor, PRMT1 inhibitor
|
Furamidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM. |
| PC-35591 |
MAK683
PRC2 EED inhibitor
|
MAK683 (MAK-683) is a potent and selective EED inhibitor with biochemical IC50 of 9 nM, and allosteric inhibitor of polycomb repressive complex 2 (PRC2), selectively binds to the domain of EED that interacts with H3K27me3). |
| PC-35520 |
PF-06855800
PRMT5 inhibitor
|
PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM. |
| PC-35432 |
Gambogenic acid
EZH2 inhibitor
|
Gambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge, shows potent antitumor activity and can effectively inhibit the survival and proliferation of cancer cells. |
| PC-35431 |
GNA002
EZH2 inhibitor
|
GNA002 (GNA-002) is a gambogenic acid (GNA) derivative that specifically and covalently binds to Cys668 within the EZH2-SET domain, trigges EZH2 degradation (IC50=1.1 uM) through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination. |
