| Cat. No. |
Product Name |
Information |
| PC-38218 |
BAY-155
menin-MLL inhibitor
|
BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503. |
| PC-38209 |
DC541
NTMT1 inhibitor
|
DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM. |
| PC-38151 |
SHIN1
SHMT1/2 inhibitor
|
SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM. |
| PC-38150 |
SHIN2
SHMT1/2 inhibitor
|
SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1. |
| PC-38010 |
MU1656
DOT1L inhibitor
|
MU1656 (MU 1656 ) is a potent, highly selective inhibitor of histone methyltransferase DOT1L with IC50 of 2 nM. |
| PC-36120 |
WDR5 WIN site inhibitor C3
WDR5 inhibitor
|
WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM. |
| PC-36119 |
WDR5 WIN site inhibitor C6
WDR5 inhibitor
|
WDR5 inhibitor C6 (WDR5-IN-4) is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM. |
| PC-36041 |
NPD13668
EZH2 inhibitor
|
NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels. |
| PC-35850 |
LEM-14-1189
NSD2 inhibitor
|
LEM-14-1189 is a LEM-14 derivative that differentially inhibits the NSDs with in vitro IC50 of 418 μM (NSD1), IC50 of 111 μM (NSD2) and IC50 of 60 μM (NSD3). |
| PC-35849 |
LEM-14
NSD2 inhibitor
|
LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3. |
| PC-35846 |
VinSpinIn
Spin1 inhibitor
|
VinSpinIn is a potent, cell active chemical probe for the Spin family protein with Kd of 10-130 nM for across the family, displays >300-fold selectivity over a panel of methyltransferases. |
| PC-35810 |
EPZ020411 dihydrochloride
PRMT6 inhibitor
|
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
