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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-BRD0639
BRD0639

Chemical Structure : BRD0639

CAS No.: 2760881-74-9

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BRD0639 (BRD-0639)

货号: PC-72495Not For Human Use, Lab Use Only.

BRD0639 (BRD-0639) is a first-in-class, specific inhibitor of interaction between PRMT5 and its substrate adaptor protein (PRMT5 binding motif) with IC50 of 13.8 uM.

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD0639 (BRD-0639) is a first-in-class, specific inhibitor of interaction between PRMT5 and its substrate adaptor protein (PRMT5 binding motif) with IC50 of 13.8 uM.
BRD0639 engages the target in cells, disrupts PRMT5-RIOK1 complexes, and reduces substrate methylation.

物理化学性质&存储条件

分子量 475.948
分子式 C21H22ClN5O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(4-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-(N-(2-(pyridin-2-yl)ethyl)sulfamoyl)phenyl)propanamide

参考文献

1. David C McKinney, et al. J Med Chem. 2021 Aug 12;64(15):11148-11168.

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