EEDi-5285 | EED inhibitor | Probechem Biochemicals

Chemical Structure : EEDi-5285

CAS No.: 2488952-40-3

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EEDi-5285 (EEDi5285)

货号: PC-72488Not For Human Use, Lab Use Only.

EEDi-5285 (EEDi5285) is a highly potent, efficacious, and orally active EED inhibitor with IC50 of 0.2 nM.

规格	价格	库存
5 mg	￥3880	In stock
10 mg	￥5780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

EEDi-5285 (EEDi5285) is a highly potent, efficacious, and orally active PRC2 EED inhibitor with IC50 of 0.2 nM.
EEDi-5285 inhibits cell growth with IC50 values of 20 pM and 0.5 nM in the Pfeiffer and KARPAS422 lymphoma cell lines, respectively, carrying an EZH2 mutation.
EEDi-5285 is approximately 100 times more potent than EED226 in binding to EED and >300 times more potent than EED226 in inhibition of cell growth in the KARPAS422 cell line.
EEDi-5285 has excellent pharmacokinetics and achieves complete and durable tumor regression in the KARPAS422 xenograft model in mice with oral administration, achieved complete tumor regression at 50 mg/kg.

物理化学性质&存储条件

分子量	479.53
分子式	C24H22FN5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(6-Cyclopropylpyridin-3-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine

参考文献

1. Rohan Kalyan Rej, et al. J Med Chem. 2020 Jul 9;63(13):7252-7267.

EEDi-5285 (EEDi5285)

生物&药学活性

物理化学性质&存储条件

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EEDi-5285 (EEDi5285)

生物&药学活性

物理化学性质&存储条件

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