Compound II757 | pan-PRMT inhibitor | Probechem Biochemicals

Chemical Structure : Compound II757

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Compound II757 (II757)

货号: PC-72716Not For Human Use, Lab Use Only.

Compound II757 (II757) is a potent, cell-active pan-PRMT inhibitor with IC50 of 5-555 nM for eight PRMTs, with the highest inhibition for PRMT4 (IC50=5 nM).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

Compound II757 (II757) is a potent, cell-active pan-PRMT inhibitor with IC50 of 5-555 nM for eight PRMTs, with the highest inhibition for PRMT4 (IC50=5 nM).
II757 competitively binds at the SAM binding site of PRMT1, inhibits PRMT1 with an IC50 of 16 nM.
II757 demonstrated modest inhibition to PRMT3 and PRMT7 (IC50=555 nM).
II757 (0-100 uM) reduced histone H4 Arg3 asymmetric dimethylation (H4R3me2a) level in HEK293 cells
II757 displays selectivity over a panel of other methyltransferases (SAHH, NTMT1, SETD7, G9a, NNMT, TbPRMT7 etc.).

物理化学性质&存储条件

分子量	537.437
分子式	C20H25BrN8O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)propyl)-3-(3-bromophenyl)guanidine

参考文献

1. Iredia D Iyamu, et al. Biomolecules. 2021 Jun 8;11(6):854.

Compound II757 (II757)

生物&药学活性

物理化学性质&存储条件

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Compound II757 (II757)

生物&药学活性

物理化学性质&存储条件

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