SGC6870 | PRMT6 inhibitor | Probechem Biochemicals

Chemical Structure : SGC6870

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SGC6870 (SGC-6870 (R-isomer))

货号: PC-72639Not For Human Use, Lab Use Only.

SGC6870 (SGC-6870 (R-isomer)) is a potent, selective, cell-active PRMT6 inhibitor with IC50 of 77 nM.

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生物&药学活性

SGC6870 (SGC-6870 (R-isomer)) is a potent, selective, cell-active PRMT6 inhibitor with IC50 of 77 nM.
SGC6870 displays outstanding selectivity for PRMT6 over a broad panel of other methyltransferases and nonepigenetic targets.
SGC6870 binds to a unique, induced allosteric pocket of PRMT6.
SGC6870 engages PRMT6 and potently inhibits its methyltransferase activity in cells.
SGC6870 is a well-characterized PRMT6 chemical probe and a valuable tool for further investigating PRMT6 functions in health and disease.

物理化学性质&存储条件

分子量	469.397
分子式	C23H21BrN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

参考文献

1. Yudao Shen, et al. J Med Chem. 2021 Apr 8;64(7):3697-3706.

SGC6870 (SGC-6870 (R-isomer))

生物&药学活性

物理化学性质&存储条件

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SGC6870 (SGC-6870 (R-isomer))

生物&药学活性

物理化学性质&存储条件

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