AMI-1 |CAS:20324-87-2 Probechem Biochemicals

Chemical Structure : AMI-1

CAS No.: 20324-87-2

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AMI-1 (Arginine methyltransferase inhibitor 1)

货号: PC-45576Not For Human Use, Lab Use Only.

AMI-1 (Arginine methyltransferase inhibitor 1) is a specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases.

规格	价格	库存
25 mg	￥1980	In stock
100 mg	￥4980	In stock
250 mg	￥7980	In stock
1 g		Get quote

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生物&药学活性

AMI-1 (Arginine methyltransferase inhibitor 1) is a specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases.
AMI-1 inhibits PRMT1 and Hmt1p with IC50s of 8.81 uM and 3.03 uM respectively.
AMI-1 increases the ratio of Bax/Bcl-2, and leads to apoptosis and loss of migratory activity in several HCC cells.
AMI-1 decreases the expression levels of H4R3me2s; strongly inhibits HCC growth in vivo.

物理化学性质&存储条件

分子量	548.4534
分子式	C21H14N2Na2O9S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 46 mg/mL
Chemical Name/SMILES	2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, sodium salt (1:2)

参考文献

1. Cheng D, et al. J Biol Chem. 2004 Jun 4;279(23):23892-9.

2. Zhang B, et al. Oncotarget. 2015 Sep 8;6(26):22799-811.

3. Zhang B, et al. J Transl Med. 2015 Nov 5;13:349.

AMI-1 (Arginine methyltransferase inhibitor 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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AMI-1 (Arginine methyltransferase inhibitor 1)

生物&药学活性

物理化学性质&存储条件

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