PF-06855800 |CAS: 1989620-04-3 Probechem Biochemicals

Chemical Structure : PF-06855800

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PF-06855800 (PF06855800)

货号: PC-35520Not For Human Use, Lab Use Only.

PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM.

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生物&药学活性

PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM.
PF-06855800 demonstrates antiproliferative activity in Z-138 cancer cells with IC50 of 1 nM,
PF-06855800 also shows anti-tumor activity in Z-138 mice xenograft models.

物理化学性质&存储条件

分子量	392.811
分子式	C19H18ClFN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,4R,5R)-2-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-1H-pyrrolo[3,2-c]pyridin-1-yl)tetrahydrofuran-3,4-diol

参考文献

1. Indrawan J. Mcalpine, et al. Abstract 4857: Discovery of PF-06855800, a SAM competitive PRMT5 inhibitor with potent antitumor activity. DOI: 10.1158/1538-7445.AM2018-4857. AACR 2018.

PF-06855800 (PF06855800)

生物&药学活性

物理化学性质&存储条件

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PF-06855800 (PF06855800)

生物&药学活性

物理化学性质&存储条件

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