CN-SAH |CAS:1985669-27-9 Probechem Biochemicals

Chemical Structure : CN-SAH

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CN-SAH (SS148, SS 148, DOT1L inhibitor CN-SAH)

货号: PC-62736Not For Human Use, Lab Use Only.

CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α..

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生物&药学活性

CN-SAH (SS148) is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α.

CN-SAH (SS148) is a potent, selective, SAM competitive inhibitor of SARS-CoV-2 nonstructural protein 14 (nsp14) with IC50/Kd of 70/50 nM, selective against 20 human protein lysine MTases.

物理化学性质&存储条件

分子量	408.433
分子式	C16H20N6O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	S-(((2S,3R,4S,5R)-5-(4-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-L-homocysteine

参考文献

1. Spurr SS, et al. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4518-22.

CN-SAH (SS148, SS 148, DOT1L inhibitor CN-SAH)

生物&药学活性

物理化学性质&存储条件

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CN-SAH (SS148, SS 148, DOT1L inhibitor CN-SAH)

生物&药学活性

物理化学性质&存储条件

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