EBI-2511 |CAS:2098546-05-3 Probechem Biochemicals

Chemical Structure : EBI-2511

CAS No.: 2098546-05-3

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EBI-2511 (EBI2511)

货号: PC-62526Not For Human Use, Lab Use Only.

EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G; significantly reduces cellular H3K27me3 levels in a dose-dependent with IC50 of 8 nM in Pfeffier cell line, IC50 of 55 nM against WSU-DLCL2.
EBI-2511 dose-dependently inhibits tumor growth at 10-100 mg/kg, po.
EBI-2511 shows a superior anti-tumor efficacy to EPZ-6438 in Pfeiffer Xenograft mouse model.

物理化学性质&存储条件

分子量	576.782
分子式	C34H48N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-(1-isopropylpiperidin-4-yl)benzofuran-4-carboxamide

参考文献

1. Lu B, et al. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102.

EBI-2511 (EBI2511)

生物&药学活性

物理化学性质&存储条件

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EBI-2511 (EBI2511)

生物&药学活性

物理化学性质&存储条件

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