MI-2-2 hydrochloride |CAS: 2308531-06-6 Probechem Biochemicals

Chemical Structure : MI-2-2 hydrochloride

CAS No.: 2308531-06-6

加入收藏

MI-2-2 hydrochloride (menin-MLL inhibitor)

货号: PC-62484Not For Human Use, Lab Use Only.

MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).

规格	价格	库存
5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
MI-2-2 inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2.
MI-2-2 suppresses growth of MLL-AF9–transformed BMCs, causes MV4:11 cells growth inhibition of with GI50 of 3 uM.

物理化学性质&存储条件

分子量	451.955
分子式	C17H21ClF3N5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine hydrochloride

参考文献

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

2. Shi A, et al. Blood. 2012 Nov 29;120(23):4461-9.

MI-2-2 hydrochloride (menin-MLL inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MI-2-2 hydrochloride (menin-MLL inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.