CMP-5 |CAS:880813-42-3 Probechem Biochemicals

Chemical Structure : CMP-5

CAS No.: 880813-42-3

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CMP-5 (PRMT5-IN-5)

货号: PC-62981Not For Human Use, Lab Use Only.

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
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生物&药学活性

CMP-5 (PRMT5-IN-5) is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.
CMP-5 (PRMT5-IN-5) displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes.
CMP-5 (PRMT5-IN-5) for inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.

物理化学性质&存储条件

分子量	315.42
分子式	C21H21N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine

参考文献

1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43.

CMP-5 (PRMT5-IN-5)

生物&药学活性

物理化学性质&存储条件

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CMP-5 (PRMT5-IN-5)

生物&药学活性

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