PFI-2 ((R)-PFI-2) hydrochloride | SETD7 inhibitor | Probechem Biochemicals

Chemical Structure : PFI-2 hydrochloride

CAS No.: 1627607-87-7

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PFI-2 hydrochloride ((R)-PFI-2 hydrochloride)

货号: PC-45489Not For Human Use, Lab Use Only.

PFI-2 ((R)-PFI-2) hydrochloride is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively.

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
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生物&药学活性

PFI-2 ((R)-PFI-2) hydrochloride is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively.
PFI-2 shows high selectivity (>1,000-fold) for SETD7 over 18 other methyltransferases and DNMT1, 500-fold more active than enantiomer (S)-PFI-2.
PFI-2 increases YAP nuclear localization, regulates YAP target genes, and phenocopys the effects of Setd7 deficiency on Hippo pathway signaling in murine embryonic fibroblasts.

物理化学性质&存储条件

分子量	535.9825
分子式	C23H26ClF4N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	6-Isoquinolinesulfonamide, 8-fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-, hydrochloride (1:1)

参考文献

1. Barsyte-Lovejoy D, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8.

2. Niu Y, et al. Sci Rep. 2017 Apr 18;7:46547.

PFI-2 hydrochloride ((R)-PFI-2 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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PFI-2 hydrochloride ((R)-PFI-2 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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